While desloratadine is less efficacious, it has the advantages of rarely causing somnolence and having a long duration of action.
Lastly, all H] and chlorpheniramine, brompheniramine, and promethazine later the same decade.
This review will concentrate on the histamine H A, Diagram of a histamine H1-receptor in a membrane showing the 7 transmembrane domains.
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Desloratadine is the most potent antihistamine (Ki 0.4 n M) followed by levocetirizine (Ki 3 n M) and fexofenadine (Ki 10 n M) (the lower the concentration, the higher potency).
Although these are often considered to be fixed values, they may be influenced by temperature and p H, and therefore, they can differ in physiologic and pathologic conditions.
But perhaps their greatest drawback is their ability to cross the blood-brain barrier and interfere with histaminergic transmission.
Histamine is an important neuromediator in the human brain which contains approximately 64,000 histamine-producing neurones, located in the tuberomamillary nucleus.
However, in chronic urticaria in which local histamine concentrations are high, the differences do seem to be important.